The mutability of enzyme active-site shape determinants
نویسندگان
چکیده
منابع مشابه
Mechanism-Based Studies of the Active Site-Directed Inhibition and Activation of Enzyme Transketolase
Derivatives of phenyl-keto butenoic acids have been reported to be inhibitors of pyruvate decarboxylase, (PDC). The inhibition of transketolase, a thiamine requiring enzyme such as PDF, by meta nitrophenyl derivative of 2-oxo-3-butenoic acid (MNPB) is reported here. These studies indicate that the inhibitor binds to the enzyme at the active site. A two-step inhibition was observed, first th...
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Features differ in their mutability. For example, a robin could still be a robin even if it lacked a red breast; but i t would probably not count as one if it lacked bones. One hypothesis to explain this differential transformability is that having bones is more critical to a biological theory than having a red breast is. We reject this hypothesis in favor of a theory of mutability based solely...
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The kinetics of charge transfer depend crucially on the dielectric reorganization of the medium. In enzymatic reactions that involve charge transfer, atomic dielectric response of the active site and of its surroundings determines the efficiency of the protein as a catalyst. We report direct spectroscopic measurements of the reorganization energy associated with the dielectric response in the a...
متن کاملMetric learning for enzyme active-site search
MOTIVATION Finding functionally analogous enzymes based on the local structures of active sites is an important problem. Conventional methods use templates of local structures to search for analogous sites, but their performance depends on the selection of atoms for inclusion in the templates. RESULTS The automatic selection of atoms so that site matches can be discriminated from mismatches. ...
متن کاملmechanism-based studies of the active site-directed inhibition and activation of enzyme transketolase
derivatives of phenyl-keto butenoic acids have been reported to be inhibitors of pyruvate decarboxylase, (pdc). the inhibition of transketolase, a thiamine requiring enzyme such as pdf, by meta nitrophenyl derivative of 2-oxo-3-butenoic acid (mnpb) is reported here. these studies indicate that the inhibitor binds to the enzyme at the active site. a two-step inhibition was observed, first the in...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2007
ISSN: 0961-8368,1469-896X
DOI: 10.1110/ps.073040307